|1977||Queen Elizabeth College, London University|
| ||PhD Theoretical Chemistry|
| ||"Perturbation Theory Methods in the Calculation of Electronic Excitation Energies in Atoms
|1974||Queen Elizabeth College, London University|
| ||BSc Chemistry, 1st Class|
|1971||A levels - Chemistry, Pure Mathematics, Applied
|1995 - 2001||Director of Bioinformatics, Oxford GlycoSciences|
|1989 - 1995||Software Section Leader, Oxford GlycoSystems|
|1987 - 1989||Senior Software Engineer, Expert Systems International|
|1982 - 1987||Senior Software Engineer, Oxford Research Systems|
|1981 - 1982||Visiting Lecturer in Theoretical Chemistry, University of London|
|1977 - 1981||Lecturer in Physical Chemistry, Kenyatta University, Kenya|
|1995 - 2001 Director of Bioinformatics, Oxford GlycoSciences (UK) Ltd|
In 1995, OGS embarked on the development the world's first large scale automated Proteomics factory,
using electrophoresis of 2D gels and mass spectrometry to identify proteins of biological and
I was appointed Director of Bioinformatics and my responsibilities included:
- The architecture and management of the software infrastructure in support of these new processes, including the Laboratory Information Management System, imaging and mass spectrometry data capture and analysis, and development of statistical and visualisation methods for end-user interrogation of the integrated data.
- Development of alliances with key academic groups and specialised software contractors, and management of collaborative development and research projects, including:
- Specialised LIMS system for Proteomics, with the bioinformatics consultancy firm, Pangea Systems
- Customisation of the Melanie image analysis software, with Ron Appel, University of Geneva
- Development of improved image analysis algorithms, with Roland Wilson, University of Warwick
- Integration of Sequest software by Jimmy Eng and John Yates for tandem spectrum interpretation, with Ruedi Aebersold, University of Washington
- Isotopic peak deconvolution in MALDI spectra, with John Skilling, MaxEnt Solutions
- Integration of Mowse mass-matching software, with Darryl Pappin, ICRF
OGS now has extensive and fully operational facilities in Oxfordshire supported by this system.
By 2001, I was directing a team of 12, comprising software developers, data analysts and bioinformaticians.
Responsibilities of the team included:
- Development, delivery and support of novel Proteomics databases and data mining applications
for major pharmaceutical company customers and internal target discovery research
- Development of image processing software in support of in-house Proteomics operations
- Improved Bayesian scoring statistics to increase sensitivity of protein mass spectral interpretation
- Bioinformatics research for new product development
|1989 - 1995 Software Section Leader, Oxford GlycoSystems|
On joining OGS, I developed instrumentation and software for the analysis of carbohydrates, becoming head of the software team of 3 in 1991. My own main projects were:
- Design and implementation of a real-time embedded operating system for custom-built
68000-based instrument controllers, used by OGS for all its instrument products.
- Calibration of LC systems for size and charge separation of carbohydrates,
and structural interpretation of the elution times of chromatographic peaks
- Design of a feedback optimising system to determine the most efficient experimental
strategy in parallel and sequential sequencing reactions.
- Design and implementation of carbohydrate sequencing analysis software application (EVE)
which coupled the biological modelling of in-vivo glycoprotein synthesis with the modelling
of rules for exo-glycosidase specificity to deduce the sequence of carbohydrates analysed
with the OGS RAAM Glycosequencer instruments.
|1987 - 1989 Senior Software Engineer, Expert Systems International|
- Support and development of an assembler implementation of the Prolog language running under DOS, and a C implementation under UNIX
- Management of a network of workstations
- Development of a graphical debugging system for the Prolog language
|1982 - 1987 Senior Software Engineer, NMR Imaging Development Group, Oxford Research Systems|
In 1984, the company was acquired by Bruker, and I worked on the original designs for their
Biospec and MedSpec range of imaging spectrometers.
- Implemented all aspects of computer control, data acquisition, Fourier analysis, data processing,
graphical display and user interface for the world's first high field Magnetic Resonance Imaging instruments.
- Worked closely with electronics engineers and NMR scientists to design interfaces
and protocols for instrument control and data analysis.
- Designed and implemented a 3D image display and processing system.
|1981 - 1982 Visiting Lecturer in Theoretical Chemistry, University of London|
|1977 - 1981 Lecturer in Physical Chemistry, Kenyatta University, Kenya|